Looking to please your palate, and get a true “sense of taste and place” on your next vacation? Then get cracking to Southwest Florida’s Charlotte Harbor & the Gulf Islands. Located along the Gulf of Mexico on Florida’s southwest coast, this string of quiet, fishing communities surrounds the state’s second largest harbor – read lots and lots of fresh fish and crabs. And lately it's been making noise as a mustdine destination for traveling foodies in search of locally caught and expertly prepared seafood.